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It is an essential cofactor for glutathione peroxidase, an enzyme and antioxidant that helps protect us from damage caused by a range of pollutants and toxins that can be present in our environment, our food, and the water we drink

Cirrhosis and liver failure can also cause orange urine

One possible explanation is that the host environment resulting from a localized excitotoxic lesion differs fundamentally from that of a chronically degenerating brain burdened with aggregated proteins such as alpha-synuclein or huntingtin

For example, skeletal muscle has very low PPP activity, as this tissue requires greater energy production and greater glycolytic pathway activity