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It is involved in several tumor processes and is high abundant in proliferating cells and in the first stage of neuronal differentiation
immunoprecipitation/Co-IP
Olaparib (AZD2281
as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD)
BDNF Protein, Human Pack Size:10 μg It is involved in severalBrain Derived Neurotrophic Factor (BDNF) is a neurotrophin that belongs to NGF beta family. BDNF can bind to its high affinity receptor TrkB and activates signal transduction cascades (IRS1 2, PI3K, Akt). BDNF can also bind to the p75NTR, but the affinity for the p75NTR receptor is lower than for TrkB. BDNF is a neurotransmitter modulator, and is vital in maturation, survival and differentiation of neuronal populations during development. BDNF also