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Here, we provide a comprehensive description of the beneficial effects of NAC in the treatment of liver diseases, addressing the first evidence of its role as a scavenger and precursor of reduced glutathione, along with studies showing its immunomodulatory action, as well as the ability of NAC to modulate epigenetic hallmarks

& Falath, W

doi: 10.1016/j.cell.2012.07.008 33 KorevaarT

ROS: the primary mediator of mitochondrial damage The cell nucleus regulates mitochondrial function via anterograde signaling, which regulates the expression of OXPHOS-related genes and activation of PPAR coactivator 1 (PGC-1) [23, 24]