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What underpins progression at the tissue, cellular and molecular levels is still unknown, but taken together, emerging data strongly point to an underlying chronic cytodegenerative process starting early and operating largely independently of overt inflammation

Neurology 2004;63:2104-10.ArticlePubMed 31

Furthermore, the levels of transcortin (or corticosteroid-binding globulin), the primary glucocorticoid-binding protein and a negative control protein, were substantially lower in IMDD patients than in controls [39]

Moreover, recent developments extend AIs role to customizing treatment strategies based on inflammatory markers, which are pivotal in managing chronic infections and systemic diseases [239]