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Mori and Pacific peoples were more likely to have an earlier onset of gout, with increased severity, tophaceous gout and accelerated joint damage, along with higher rates of co-morbidities

Through a variety of physiological pathways involving many receptors, such as P2X7, toll-like receptor 4 (TLR4), and other unidentified receptors, hemolyzed red blood cells release heme and ATP, which act as damage-associated molecular patterns (DAMPs) and activate endothelial cells, neutrophils, and macrophages

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all route-specific efficacy claims derive from rodent or cell studies