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Molecular Microbiology, 39(3), 533541

Environmental triggers induce mucosal stress, leading to protein citrullination, antigen presentation by dendritic cells, and subsequent autoimmune activation

Most of the circulating IGF-I is produced by the liver, yet ablation of this source in mice (the LID mouse, for Liver IGF-I Deficient) does not have a dramatic effect on muscle size, nor on general postnatal body growth 30,31 , indicating that skeletal muscles can rely on other pools of IGF-I

This process entails a complex gene network responsible for sensing and repairing errors, ensuring genome integrity and cell survival [103]