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Analysis of 14 paired liver biopsies revealed significantly lower baseline peripheral mtDNA copy number in NASH versus simple steatosis patients, establishing an association between mitochondrial dysfunction and disease severity

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Safety concerns include a 2 - 3-fold higher infection risk and tuberculosis reactivation (1 - 2% incidence) (6)

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A small helix that is parallel to the membrane, known as the S4S5 linker helix, connects each pVSD to the pore domain

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siRNAs were transduced to HT1080 cells with lipofectamine3000 (Sigma) according to the manufacturers protocol

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