PMID: 30816443 J Med ChemDiscovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia
I have pernicious anaemia and have 4 weekly injections which just about tick me over to the next one
Post-therapy measurement starts now (we have baseline for the same): + telomere length + biological organ ages + speed of aging (DNA Methylation) + whole body MRI (blueprint ezra scan) + SpO2 (peripheral capillary oxygen saturation) + microbiome + pro inflammation: TNF-a, IL-6, hsCRP, myeloperoxidase, LpPLA2, oxLDL + anti inflammation: IL-10 + mitochondrial function + telomere length + enhanced antioxidant function - Glutathione + neurocognitive - p-Tau217, S-100B + angiogenesis: VEGF + lithium and thyroid panel + blood: b12, glucose, serum, uric acid, serum, creatinine, serum, gfra (egfr), bun/creatinine ratio, sodium, serum, potassium, serum, chloride, serum, carbon dioxide, total, calcium, serum, protein, total, serum, albumin, serum, globulin, total, bilirubin, total, alkaline phosphatase, s (alp), ast (sgot), alt (sgpt), folate (folic acid) serum, interleukin-6, plasma, coenzyme q10, total, oxidized ldl, total glutathione, p-tau217, vegf, plasma, myeloperoxidase (mpo), lp-pla2 activity, s-100b protein, serum, tnf-alpha, interleukin-10, serum, mmp9, il-6 (serum), hscrp, dhea, dht, testosterone, igf-1, cortisol, cbc, thyroid panel, lithium We cant unsee it
Upon delivery of Epithalon, it was observed that the incidence of the chromosomal aberrations in the bone marrow of SAMP-1 mice with accelerated aging appeared to be almost 2 times higher than the other two models
