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Acknowledgements This study was funded by the German Cancer Aid, Deutsche Krebshilfe, Project ID 70113697 (to D.A.R.) and by the German Research Foundation, Deutsche Forschungsgemeinschaft (DFG), CRC1479 (Project ID 441891347, P17 to D.A.R., P01 to R.Z., P06 to O.G., S01 to M.B

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