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Assessment of running wheel activity For assessment of running wheel behavior, we only included mice which at baseline ran at least 0.1km/day

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As IGF-1 LR3, being a modified and more powerful version of natural IGF-1, reproduces these effects without affecting levels of growth hormone secretion by the pituitary gland itself

The IGFs mechanism of action is mediated through IGF/IGFR binding, kinase activation and the initiation of intracellular signaling via the AKT signaling pathway