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5) Subclinical hepatotoxicity at guideline-concordant doses Trials and experience show transaminase elevations (often asymptomatic, reversible) after several days near 4,000 mg/day

For instance, it is believed that epithelial cells can reprogram neighbouring stromal fibroblasts to increase the fibroblasts secretion of pyruvate and lactate, so that the epithelial cells may take up these energy-rich metabolites themselves (Pavlides et al, 2009)

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