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used off-label for adult GH deficiency management), tesamorelin (FDA-approved for HIV-associated lipodystrophy under the brand Egrifta SV), and mecasermin (approved for severe primary IGF-1 deficiency in children) [15, 19]

Yan Chen, [email protected] These authors have contributed equally to this work This article was submitted to Cellular Biochemistry, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers