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directly delivered purified proteasomes into cells through mesoporous silica nanoparticle-mediated endocytosis, and they found that extraproteasomal transfer reduces tau aggregates and promotes cell survival against tau-induced proteotoxic stress (Han et al., 2014)

doi: 10.1038/s41569-020-0340-9 187 LinRZImGBLuoACZhuYHongXNeumeyerJet al

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[6] Set that beside the 24 minute half-life and the mismatch is stark: a compound essentially cleared from plasma within 20 minutes, reported to begin acting at 60 minutes and to persist for up to 20 hours