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However, in contrast to other anxiolytics such as benzodiazepines, somatostatin exerts pro-cognitive effects under healthy (Liguz-Lecznar et al., Response to stress Activation of CRF signaling CRF expression is upregulated in the hypothalamus and the peptide released into the median eminence under conditions of stress leading to pituitary ACTH and subsequently adrenal glucocorticoid hormone release (cortisol in humans and corticosterone in rodents) (Turnbull and Rivier, 1997

BPC 157 (10 g/kg and 10 ng/kg), L-NAME (5 mg/kg), and L-arginine (100 mg/kg) were administered per se or combined with each other while controls were administered equivolume saline (5 mL/kg) intraperitoneally

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