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R NAT2 is the more clinically relevant because it metabolizes the majority of amine drugs (isoniazid, hydralazine, procainamide, sulfonamides, caffeine)

While these represent uncontrolled single-person reports rather than systematic evidence, they align with the preclinical research findings

CrossRef Continuous glucose monitoring in Korean pediatric patients with type 1 diabetes: current landscape and clinical implications Hwa Young Kim, Jaehyun Kim Clinical and Experimental Pediatrics.2025

LDL oxidation is a major factor in the development of ED in hyperlipidemia, with high levels of oxidatively modified LDL (oxLDL) observed in penile tissue from patients [132] and animal models [130]