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In cultured fibroblasts, GHK-Cu increased collagen synthesis at strikingly low concentrations the effect began between roughly 10 -12 and 10 -11 M and peaked near 10 -9 M, independent of any change in cell number, meaning the peptide upregulated matrix production per cell rather than simply growing more cells

Rivera FB, Cruz LLA, Magalong JV, et al

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When investigating B12 deficiency, it's important to check folate status as well, as the two deficiencies often coexist