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Subsequent work by Heffernan and coworkers (2001) confirmed the peptides effects in obese mouse models, with chronic administration associated with reduced body weight gain and decreased adiposity without concurrent changes in food intake

References Htut TW, Thein KZ, Oo TH

[13] In a newly diagnosed vitamin B 12 -deficient patient, normally defined as when serum levels are less than 200 pg/ml, daily IM injections of hydroxocobalamin up to 1,000 g (1 mg) per day are given to replenish the body's depleted cobalamin stores

The NHS advises that supplements containing up to 2mg (2000 micrograms) daily are safe for most people