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Other conditions known to influence expression of GCLC at the transcriptional level include treatments with antioxidants such as butylated hydroxyanisole [74,75], 5,10-dihydroindeno [1,2-b]indole and tert-butyl hydroquinone (TBH) [44,76,77], inducers of Phase II detoxifying enzymes such as -naphthoflavone (-NF) [78], formation of Michael reaction acceptors (containing an electrophilic electron-deficient center that is susceptible to nucleophilic attack) by treatment with diethyl maleate (DEM) to produce GSH conjugates [75], heat shock [79], zinc [80], melatonin [81], curcumin [82], and lipid peroxidation products such as 4-hydroxynonenal (4-HNE), 15-deoxy- 12,14 -prostaglandin J 2 (15d-PGJ 2 ) [8386], trivalent arsenite (As 3+ ) [87], and ajoene, a major compound in garlic extracts [88]

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It has been found to be beneficial in treating conditions such as melasma, acne, hyperpigmentation, rosacea, and eczema

Hence, the aim of this review is to depict the current molecular and pharmacological knowledge on glutathione, focusing on the available studies related to its therapeutic activity in NAFLD