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Advances in structural biologyparticularly the integration of AlphaFold and RoseTTAFoldhave enabled rational drug design targeting key ferroptosis effectors such as ACSL4, LOXs, and system Xc components

A second interface between the CNS and periphery, formed by the epithelial cells of the choroid plexus facing the CSF, the CSF per se , and the highly permeable ependyma in the brain ventricles, constitute the BCB (Abbott et al., 2010

The global burden of disease attributable to high body mass index in 195 countries and territories, 1990-2017: An analysis of the Global Burden of Disease Study