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What's missing: No human pharmacokinetic data No human safety data No optimal dose for humans (mouse 20mg/kg = ~150mg in a 75kg human if dose-equivalent, but mouse-to-human scaling for small molecules is unreliable) No drug interaction data No long-term safety data Buyers in this category are doing biohacker-tier self-experimentation with limited data

For example, magnetic resonance imaging (MRI) devices are specifically contemplated within the scope of the embodiments, wherein the MRI devices (for example, 3 Tesla MRI devices) are capable of evaluating Meniere Disease progression and subsequent treatment with the pharmaceutical formulations disclosed herein