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BMJ Open 13 , e072110 (2023)

It should be kept away from strong chelators (such as high levels of EDTA and related sequestrants), reducing sugars, thiol-bearing actives, and high concentrations of direct acids (for example ascorbic acid or alpha-hydroxy acids at low pH), all of which can compete for the copper center or disrupt the peptide-metal bond and shift the characteristic blue color toward brown or colorless degradation products

The gut microbiota metabolite capsiate regulate SLC2A1 expression by targeting HIF-1 to inhibit knee osteoarthritis-induced ferroptosis