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Drug Interactions Drug Interactions Affecting Co-administered Drugs: Antibiotics: Thiamine, riboflavin, pyridoxine, niacinamide and ascorbic acid decrease activities of erythromycin, kanamycin, streptomycin, doxycycline and lincomycin (7.1) Bleomycin: Ascorbic acid and riboflavin may reduce the activity of bleomycin (7.1) Levodopa: Pyridoxine may decrease blood levels of levodopa and levodopa efficacy may decrease (7.1) Phenytoin: Folic acid may decrease phenytoin blood levels and increase risk of seizure (7.1) Methotrexate: Folic acid may decrease response to methotrexate (7.1) Drug Interactions Affecting Vitamin Levels: Use In Specific Populations See 17 for PATIENT COUNSELING INFORMATION

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