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1952 Red Vines brand launched with original cherry-based red twist flavor

The Guidance expressly provides that it does not address products that are not tobacco products and that only [l]iquids that do not contain nicotine or other material or derived from tobacco, but that are intended or reasonably expected to be used with or for the human consumption of a tobacco product , may be components or parts and, therefore, subject to FDAs tobacco control authorities. (Emphasis added)

Since the risk for lung cancer (but also other tobacco smoke-related diseases) appears to be dose-dependent, the concentration reduction of the most important carcinogens in cigarette smoke may lower the risk of tobacco smoking