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Furthermore, a meta-analysis including three large randomized controlled phase 3 clinical trials of anti-PD(L)1 immunotherapy comprising over 1600 patients with advanced HCC (CheckMate-459, 556 Imbrave150, 550 and KEYNOTE-240 551 ) revealed that although immunotherapy improved survival in the overall population, but not improve survival in patients with non-viral HCC

Tsitkanou S, Della Gatta PA, Russell AP