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On the other hand, higher losses of total folate after treatment may occur because of leakage due to matrix disruption and oxidative degradation of monoglutamate forms due to their lower stability 37,75,117,180,234,394,399,403,414,473,474,475,477,480,533,893

In a study conducted by Labib et al., four innovative series of tetrazole analogs were developed by bioisosteric substitution of the sulfonamide moiety in celecoxib (Figure 5) with tetrazole, incorporating various core structures such as chalcone, isoxazole, and pyrazole (96)

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