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doi: 10.3389/fcell.2021.625036 43 Mohan JeenaLKumarDRahangdaleSPratap SinghAChandra SarkhelB

2.1.3 Inhibited pyroptosis and inflammation of follicular granulosa cells Furthermore, researchers have discovered that metformin has the potential to enhance follicle development and induce ovulation by suppressing pyroptosis and inflammation of follicular granulosa cells

Therapeutic strategies targeting this cycle -such as Nrf2 activators (sulforaphane), mitochondrial antioxidants (MitoQ), and AGE inhibitors (aminoguanidine)- highlight the dual role of OS as interventions early in DM, which can improve -cell function, while later-stage treatments primarily mitigate complications