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Recent studies have indicated that excess Fe 2+ can donate electrons to hydrogen peroxide (H 2 O 2 ) to generate hydroxyl radicals, which have high reactivity with biological molecules, such as proteins, lipids, and nucleic acids, leading to lipid peroxidation and the eventual development of ferroptosis ( 2+ is also involved in the catalytic subunit of lipoxygenase (ALOX)

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Conversely, InsRec crosstalk with angiotensin II receptors (ATR1) has been mechanistically linked to IR-promoting signaling and meta-inflammatory amplification [221]

STAT3 signaling is a major activator of immunosuppressive cells which are able to counteract the chronic low-grade inflammation associated with the aging process