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Adherence is the key problem!If 70% of the patient discontinue the treatment after 6-12 month and regain the weight very quickly, handling the adherence weakness is much more helpful to the patient's health than another 3% weight loss.Alma's smart capsule we can probably load GLP1 or Amylin on a once / twice weekly oral dose

At doses as low as 1 mg, 2 h before DLMO may be the most effective dosing time to advance the rhythm [89]

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However, advanced formats like liposomal delivery protect the molecule, allowing for significantly higher absorption at the cellular level