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In addition, ALRN-6924, as the only stapled peptide drug that has entered clinical trials so far, has a serious drawback of not being able to produce long-term inhibition of related PPI in vivo

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In line with this, a study using postmortem brain tissues from PD patients and controls, as well as monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), found over-expression of ICAM-1 in the substantia nigra of patients with PD and in the MPTP monkeys [156]

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