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however, it significantly elevates the incidence of aneuploidy in blastocysts ( 2 The impact of oxidative stress on oocyte development While advancements in assisted reproductive technology have addressed infertility issues in some younger women, they cannot fully compensate for the fertility decline observed in women of advanced reproductive age, particularly those over 40 years of age ( Figure 1 )

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doi:10.1136/gutjnl-2014-308209 45

This route offers pharmaceutical-grade purity and potency, concentrations well above OTC products (typically 2 to 10 percent or more versus cosmetic-grade 0.01 to 1 percent), physician evaluation before prescribing, ongoing medical oversight, and full FDA compliance