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d : FT282, n = 8 technical replicates representative from 3 independent experiments

When the relative bioavailability for F1 was compared to that of pure oral drug, it was found to be 9.77

This therapeutic effect was mechanistically linked to reductions in pro-inflammatory cytokines (TNF-, IL-1), enhancement of antioxidant defenses (e.g., increased superoxide dismutase activity), suppression of apoptosis via caspase-3 inhibition, and modulation of NF-B pathwayscollectively yielding neuroprotection and symptomatic relief ( Curcumin shows therapeutic potential for managing peripheral neuropathic pain through multiple mechanisms (Zhang et al., 2020b)

For example, the analysis of gene expression of APX in a thermo-tolerant and thermo-susceptible variety of Brassica spp, T