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Abstract Background: Although oxidative stress is known to contribute to cancer, and endogenous and exogenous antioxidants are thought to prevent tumorigenesis by suppressing oxidative stress-induced DNA damage, antioxidants have also been reported to show negative effects on tumor formation, necessitating characterization of the causal associations between antioxidants and cancer risk

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It plays a role in metabolism of amino acids and is a necessary co-factor in the folate cycle, lack of which can lead to anaemia