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Both peptides are typically administered intranasally using precision nasal spray dispensersthis route bypasses first-pass hepatic metabolism and delivers peptides directly to the olfactory epithelium, where they cross into the central nervous system within minutes via olfactory nerve pathways

Tolerance and Hedonic Adaptation Repeated exposure to the same rewarding stimuli leads to tolerance, requiring increasingly intense experiences to achieve similar pleasure levels

Effects of delta sleep-inducing peptide on pre- and postsynaptic glutamate and postsynaptic GABA receptors in neurons of the cortex, hippocampus, and cerebellum in rats

Sci Rep 8:110