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Evidence indicates that in severe cases repeated concussions can encourage mild cognitive impairment (MCI), a predisposing condition often preceding AD [37]

Materials and methods Rat model of soft tissue injury Animal studies and procedures were carried out in accordance with an approved protocol from the Institutional Animal Care and Use Committee (IACUC) at the Fourth Military Medical University (IACUC-20220505)

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This consistency supports the validity of both models in revealing mechanisms underlying antidepressant drug actions