In terms of specific regulatory effects, the protective role of mitophagy is mainly reflected in a state of moderate activation: when cells are subjected to mild stress and mitochondria undergo local damage, mitophagy can specifically recognize and clear damaged, depolarized mitochondria, effectively reducing the abnormal release of ROS and the cytoplasmic leakage of mtDNA
Given the known role of BDNF in pain modulation, especially its role as a defense mechanism for pain, we surmised that the decreased serum BDNF after treatment in the FM patients could be related to pain modulating, not the improvement in depression and related neuroplasticity, because depression improvement needs more time and higher dose of antidepressants
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Tian R, Guo S, Chen S, Zhang X, Li J, Wang Y (2025) Natural products as Nrf2 modulators for ferroptosis inhibition in renal disease therapy: recent progress and future prospects