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Our identification of the Human-SFB-refML lineage in South America 80,84,89 , including in the indigenous Tsimane horticulturalists of the Amazon in Bolivia, children from the Amazonian lowlands in Peru, and individuals from the Amazonas Guahibo Amerindians in Venezuela, is also intriguing (Supplementary Data 4)

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Activation of endosomal TLR7/8 during SARS-CoV-2 may increase the inflammatory response resulting in severe and potentially lethal immunopathological effects in COVID-19 patients as consequence of the simultaneous release of pro-inflammatory cytokines and chemokines