In some embodiments, the formulation or composition has a retention time in the ear of about 5 minutes, about 15 minutes, about 30 minutes, about 1 hour, about 4 hours, about 6 hours, about 12 hours, about 18 hours, about 1 day, about 2 days, about 3 days, about 4 days, about 5 days, about 6 days, about 7 days, about 10 days, about 12 days, about 14 days, about 18 days, about 21 days, about 25 days, about 30 days, about 45 days, about 2 months, about 3 months, about 4 months, about 5 months, about 6 months, about 9 months or about 1 year
Antibody titer was determined as the highest dilution factor for each mouse with a higher OD value than background, where the background is the mean absorbance of mice given NaCl plus 5x the standard error of the mean of the same observations
Myrosinase is active at alkaline conditions in the oral cavity but inactivated in the stomach due to acidic conditions
As a consequence, the use of NSAIDs was, and is still, discouraged while the alternative adoption of paracetamol is still preferred
