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Numerous other studies have looked into melatonins effectiveness in promoting quality sleep, finding that melatonin supplementation can aid disrupted circadian cycles, 14 decrease daytime sleepiness, 15 improve sleep quality for secondary sleep disorders, 16 and improve sleep-wake rhythm and endogenous melatonin rhythm

PMID 22179958

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Uric acid stimulation can promote the occurrence of oxidative stress in VSMCs and superoxide anion release is an upstream target mediator of oxidative stress (57-59)