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If switching the route of administration and dosage don't help, you may also have like a substrate issue

Additional preclinical work published in Cell Chemical Biology evaluated NNMT inhibition in similar diet-induced obesity models and confirmed the pattern: significant reductions in body weight gain, adipose tissue expansion, and circulating triglycerides compared to untreated controls

The average serum vitamin B 12 concentration was 446 pmol/L

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