In an uncontrolled clinical trial in 23 women with rosacea, use of a topical 0.05% retinaldehyde cream once daily for six months led to modest improvement in rosacea-related facial redness and telangiectasia in 75% of participants
HINNAO has developed a superior supplementation with a delivery mechanism that equals an infusion, without the need for needles or cannulas

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The formulations evolved into three products with distinct functions, becoming the Radiance Range