These effects have been recently associated with several molecular pathways [10,11,20,58,59,60,61,62,63,64,65,66], in particular with the increased expression and internalization of VEGFR2, and the activation of the VEGFR2-Akt-eNOS signaling pathway [60,61], interacting particularly with the NO [49] and prostaglandins systems [50]
This can be tested using a holo TC or MMA urine test, which only measure the usable B12 (holo TC) or the metabolic product (MMA test)
Alternative protocols for different goals Not everyone follows the standard loading approach
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