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Additional research indicated that the proper function of STAT3 is critical for maintaining intestinal homeostasis, and constitutive activation of the STAT3 signaling pathway in epithelial cells reduces tight junction protein expression within endothelial cells, consequently enhancing vascular permeability and contributing to tissue damage and disease progression (Spalinger et al., 2021)

First, we could not assess the mechanisms through which additional mutational backgrounds, particularly in the context of PIK3CA mutations, or the immune environment may alter the effects of aspirin

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