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LPS treatment impaired the uptake process of DA by 45% and this decrease was strongly hindered by VPA pretreatment in a dose-dependent manner

Experimental evidence shows that dietary Trp supplementation improves motor deficits, enhances tyrosine hydroxylase expression, inhibits NF-B activation in the substantia nigra, and lowers circulating pro-inflammatory cytokines in toxin-induced, animal PD models [167]

Most researchers experience profound reductions in hunger and food noise within the first few weeks of administration