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Abstract The acute effects of smoking a low- or high-nicotine cigarette on hypothalamicpituitaryadrenal (HPA) hormones, subjective responses, and cardiovascular measures were studied in 20 healthy men who met American Psychiatric Association Diagnostic and Statistical Manual IV criteria for nicotine dependence

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And this force has become sufficient to help reverseagainst all the money and the machinery of mass persuasion and the commercial and political influence of a most formidable American industry, against the vast inertia of government, even against the habituation, reluctant or otherwise, of millions of regular smokersthe growth of a vast and, it once seemed, almost universally accepted and apparently ineradicable personal custom

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