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Trientine diHClide is another common copper chelator used for treating Wilson's disease (132), which can selectively bind Cu2+ ions to improve mitochondrial function in patients with hypertrophic cardiomyopathy (73), as well as restore mitochondrial function and normalize myocardial expression and enzymatic activity of proteins involved in energy metabolism among diabetic patients (133)

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Flavodoxins are present in bacterial cells of various species but are absent in animals and humans