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A polymorphic CA in the IGF-I gene is associated with gender-specific differences in body height, but has no effect on the secular trend in body height

In cancer cells, TrxR1/2 inhibition by Hdy-7 induces cytotoxic autophagy through elevated ROS and TFEB activation, which can be reversed by antioxidants or p53 knockdown, illustrating the redox sensitivity of this pathway

These protective effects are attributed primarily to their antioxidative, anti-inflammatory, and antiapoptotic properties, providing scientific support for the use of TCM in thyroid disease management