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Pascual, the lead researcher in the study, smoking is a precipitating factor of this type of headache, as the prevalence of active smokers is one third higher in migraine sufferers and there is a direct relationship between the number of cigarettes consumed and the frequency of migraine attacks. Though there is no proven mechanism for why smoking increases the frequency of migraines, it is possible that the nicotine and other harmful substances in cigarettes generate excessive amounts of free radicals, causing substantial oxidative stress, which is known to contribute to inflammation, which may then affect the nerves

Other than nicotine, cigarette smoke contains harmful chemicals that can lead to cancer

Check the tobacco for discoloration, unusual dark spots, or mold

This directive takes into account the WHO Framework Convention on Tobacco Control FCTC (described below) and adds several rules on the sale of tobacco products and electronic cigarettes to the previous directive, adopted in 2001