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In reality, the treatment of underlying vector-borne infection leading to cyclical Herx flares may be the main issue

The evidence is unclear or shows little to no benefit from using B12 supplementation, but more research is needed in these areas

it is naturally occurring, nontoxic, and is active at a very low nanomolar concentration.11 Another piece of research described GHK-Cu as a safe, inexpensive, extensively studied compound.3 These conclusions primarily apply to topical GHK-Cu, but even with injectables, the lack of serious adverse events in animal subjects points to a general tolerability regardless of the route of administration

Oral high-dose B12 (1,000-2,000 g daily) may be considered as an alternative for patients with dietary deficiency without malabsorption who prefer this route or cannot tolerate injections