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(123) found that in BCAECs, TPs activated ERK1/2 and inhibited p38MAPK signaling in a dose-dependent manner, downregulating Cav-1 expression and thereby protecting endothelial cells

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Proinflammatory properties of glutathione peroxidase-4 Notably, the 718C allele of the GPX4 gene was found to be associated with the increased levels of lymphocyte lipoxygenase products implying that the polymorphism can modulate inflammatory processes through the regulation of the biosynthesis of leukotrienes, thromboxanes and prostaglandins

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