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Chang CH, Qiu J, OSullivan D, Buck MD, Noguchi T, Curtis JD, et al

Dose selection depends on injury severity, research model, and individual tolerance

Additionally, as the closely interrelated increased pressure in the three body cavities was rapidly transmitted through the venous system [23] (and thereby, the venous system can be seen as a therapy target [14,15,16,17,18,19,20,21,22,23]), the brain swelling and lesions and increased pressure in the superior sagittal sinus may induce a comparable deadly syndrome [20]